منابع مشابه
Calmodulin and calcium channel blockers.
IONIZED calcium regulates many cellular processes, such as cell motility, muscle contraction, axonal flow, cytoplasmic streaming, neurotransmitter release, endocytosis, andexocytosis. Intracellular Ca concentrations under steady state conditions are low, usually below 10" M. Upon stimulation, the Ca concentration increases transiently and apparently signals an appropriate response, which is oft...
متن کاملInvolvement of Calcium and Calmodulin in Membrane
The prospect that Ca+2 promotes senescence by activating al has beene d using cut pea (Pisan satiwm co Aska) foliasge a model system. Senescence was induced by severing 17-day-old plats from their roots and mainting them in aqueous test solu in the dark for an additiona 4 days. Treatment of the foliage with the Ca2+ ionophore (A23187) during the senescence-inductio period promoted a laterd phas...
متن کاملIntracellular Calcium and Calmodulin Involvement in Protoplast
45ca2+ uptake was compared between fusogenic and nonfusogenic Daucus carota L. protoplasts. Fusogenic protoplasts took 10 minutes to reach calcium equilibrium compared to 5 minutes in the nonfusogenic protoplasts. Intracellular stores of calcium were manipulated by isolating protoplasts in different calcium regimes. Lowering of intracellular calcium lowered fusion potential, while raising intra...
متن کاملCalcium Binding Domains of Calmodulin
Terbium, a trivalent lanthanide, effectively substituted for Ca2+ in calmodulin as judged by several criteria: intrinsic fluorescence spectra, altered mobilities on polyacrylamide gel electrophoresis, formation of a stable complex with troponin I or calcineurin, and stimulation of phosphodiesterase. Calmodulin harbors four Caa+ binding domains; domains I and I1 contain no tyrosine, whereas doma...
متن کاملCalcium/Calmodulin A Synaptic Antidepressant?
Synaptic depression contributes to short-term changes in synaptic efficacy during sustained activity. Sakaba and Neher (2001) have characterized two kinetically distinct pools of releasable vesicles whose depletion underlies depression at a CNS synapse. Calcium/calmodulin dramatically accelerates replenishment of one of these pools--and hence recovery from depression.
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ژورنال
عنوان ژورنال: Nature
سال: 1981
ISSN: 0028-0836,1476-4687
DOI: 10.1038/294693a0